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antifibrosis compound library  (TargetMol)


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    TargetMol antifibrosis compound library
    Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 <t>antifibrosis</t> compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.
    Antifibrosis Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti-fibrosis+compound+library/Anti-Fibrosis+Compound+Library/pmc12358629-72-9-15
    Average 93 stars, based on 1 article reviews
    antifibrosis compound library - by Bioz Stars, 2026-09
    93/100 stars

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    1) Product Images from "3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis"

    Article Title: 3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis

    Journal: Biochemistry and Biophysics Reports

    doi: 10.1016/j.bbrep.2025.102191

    Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 antifibrosis compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.
    Figure Legend Snippet: Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 antifibrosis compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.

    Techniques Used: Biomarker Discovery, Control, Concentration Assay, Collagen Gel Contraction Assay

    Related Articles

    other:

    Article Title: 3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis
    Article Snippet: , and S4317). BMP4 was supplied by R&D Systems (Minneapolis, MN, USA; 345-FG). CHIR99021, 8-bromo-cAMP, and retinoic acid were supplied by Tocris (Bristol, UK; 4423, 1140, and 0695). FGF7 was supplied by Peprotech (Rocky Hill, NJ, USA; 100-19). Accutase was purchased from Merck (Rahway, NJ, USA; SCR005).The antifibrosis compound library was supplied by TargetMol Chemicals, Inc. (Boston, MA, USA).



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    antifibrosis compound library  (TargetMol)
    93
    TargetMol antifibrosis compound library
    Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 <t>antifibrosis</t> compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.
    Antifibrosis Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/anti-fibrosis+compound+library/Anti-Fibrosis+Compound+Library/pmc12358629-72-9-15
    Average 93 stars, based on 1 article reviews
    antifibrosis compound library - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier

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    Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 antifibrosis compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.

    Journal: Biochemistry and Biophysics Reports

    Article Title: 3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis

    doi: 10.1016/j.bbrep.2025.102191

    Figure Lengend Snippet: Validation of hits that conferred resistance to TGF-β1-induced viability in alveolar organoids (A) Picture and absorbance of WST-8 assay after 48 h exposure to TGF-β1 or SB431542. Absorbance was measured at 450 nm. n = 3 experiments. Student's t -test compared to control. (B) Absorbance of WST-8 assay after 48 h exposure to TGF-β1 or 320 anti-fibrosis compounds. Compounds were screen at a concentration of 10 μM. Hit drugs had higher optical density (OD) than negative drugs. The cut-off value (dashed line) is OD = 0.65 (C) The 10 hits among 320 antifibrosis compounds (D) Bright-field images of alveolar type II organoids treated with TGF-β1 or the 9 hit drugs. (E) Gel contraction assay was performed on fibroblasts using the 7 antifibrotic hit drug.

    Article Snippet: Accutase was purchased from Merck (Rahway, NJ, USA; SCR005).The antifibrosis compound library was supplied by TargetMol Chemicals, Inc. (Boston, MA, USA).

    Techniques: Biomarker Discovery, Control, Concentration Assay, Collagen Gel Contraction Assay